MC-GGFG-AM-(10Me-11F-Camptothecin), CAS [[2873460-70-7]] Preis auf Anfrage

Produktübersicht

• Artikelname: MC-GGFG-AM-(10Me-11F-Camptothecin), CAS [[2873460-70-7]] Preis auf Anfrage
• Artikelnummer: BYT-ORB1982290
• Hersteller Artikelnummer: orb1982290
• Alternativnummer: BYT-ORB1982290-5,BYT-ORB1982290-50
• Hersteller: Biorbyt
• Kategorie: Biochemikalien

Produktbeschreibung

MC-GGFG-AM-(10Me-11F-Camptothecin) serves as a linker-payload conjugate in the synthesis of ZW251, an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 comprises a humanized IgG1 antibody linked to ZD06519, a novel camptothecin-based topoisomerase 1 inhibitor, through a maleimide-anchor and a cleavable glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) linker. ZW251 demonstrates strong affinity for GPC3 in both human and cynomolgus monkey cells, characterized by rapid internalization in GPC3-positive Hepatocellular Carcinoma (HCC) cell lines and induces bystander-mediated killing of GPC3-negative cancer cells.

Produkteigenschaften

• Molekulargewicht: 1038.04
• CAS Nummer: [2873460-70-7]
• Formel: C51H56FN9O14
• Target-Kategorie: Drug-Linker Conjugates for ADC,Topoisomerase