MC-GGFG-AM-(10Me-11F-Camptothecin), CAS [[2873460-70-7]] Preis auf Anfrage

Product Overview

• Article Name: MC-GGFG-AM-(10Me-11F-Camptothecin), CAS [[2873460-70-7]] Preis auf Anfrage
• Biozol Catalog Number: BYT-ORB1982290
• Supplier Catalog Number: orb1982290
• Alternative Catalog Number: BYT-ORB1982290-5,BYT-ORB1982290-50
• Manufacturer: Biorbyt
• Category: Biochemikalien

Product Description

MC-GGFG-AM-(10Me-11F-Camptothecin) serves as a linker-payload conjugate in the synthesis of ZW251, an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 comprises a humanized IgG1 antibody linked to ZD06519, a novel camptothecin-based topoisomerase 1 inhibitor, through a maleimide-anchor and a cleavable glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) linker. ZW251 demonstrates strong affinity for GPC3 in both human and cynomolgus monkey cells, characterized by rapid internalization in GPC3-positive Hepatocellular Carcinoma (HCC) cell lines and induces bystander-mediated killing of GPC3-negative cancer cells.

Product Properties

• Molecular Weight: 1038.04
• CAS Number: [2873460-70-7]
• Formula: C51H56FN9O14
• Target: Drug-Linker Conjugates for ADC,Topoisomerase