Hydroxy bosentan (Ro 48-5033) is the primary active metabolite of the endothelin receptor antagonist bosentan, formed via hepatic CYP450 metabolism. It retains approximately 10-20% of the parent drugs pharmacological activity. This metabolite is utilized in research applications investigating bosentans pharmacokinetics, metabolic pathways, and comparative efficacy in both in vitro and in vivo experimental models.
Molekulargewicht:
567.61
CAS Nummer:
[253688-60-7]
Formel:
C27H29N5O7S
Target-Kategorie:
Endogenous Metabolite,Others
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