Hydroxy bosentan (Ro 48-5033) is the primary active metabolite of the endothelin receptor antagonist bosentan, formed via hepatic CYP450 metabolism. It retains approximately 10-20% of the parent drugs pharmacological activity. This metabolite is utilized in research applications investigating bosentans pharmacokinetics, metabolic pathways, and comparative efficacy in both in vitro and in vivo experimental models.
Molecular Weight:
567.61
CAS Number:
[253688-60-7]
Formula:
C27H29N5O7S
Target:
Endogenous Metabolite,Others
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