PD-L1-IN-3 (Compound 4a) functions as an inhibitor of the PD-1/PD-L1 axis, with an IC50 value of 4.97 nM for PD-L1 inhibition and an EC50 value of 2.70 µM for Jurkat T cell modulation. It antagonizes the PD-1/PD-L1 interaction by binding to the PD-L1 dimer, obstructing PD-1 signaling. This compound is utilized in research pertaining to lung cancer and melanoma.
Molekulargewicht:
373.85
Reinheit:
99.47%
CAS Nummer:
[2953044-29-4]
Formel:
C19H15ClFN2OS
Target-Kategorie:
PD-1/PD-L1
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