Tagarafdeg (CFT1946) is an orally bioavailable PROTAC degrader that selectively targets and degrades multiple mutant BRAF variants, including Class I (V600E), Class II (G469A), and Class III (G466V) mutations, as well as the p61 splice variant. It demonstrates high proteome selectivity, sparing wild-type BRAF and CRAF, and potently inhibits tumor cell proliferation in preclinical cancer research models.
Molekulargewicht:
958
Reinheit:
>99.99% (May vary between batches)
CAS Nummer:
[2882165-79-7]
Formel:
C45H49F2N11O9S
Target-Kategorie:
Raf,PROTACs
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
