Tagarafdeg (CFT1946) is an orally bioavailable PROTAC degrader that selectively targets and degrades multiple mutant BRAF variants, including Class I (V600E), Class II (G469A), and Class III (G466V) mutations, as well as the p61 splice variant. It demonstrates high proteome selectivity, sparing wild-type BRAF and CRAF, and potently inhibits tumor cell proliferation in preclinical cancer research models.
Molecular Weight:
958
Purity:
>99.99% (May vary between batches)
CAS Number:
[2882165-79-7]
Formula:
C45H49F2N11O9S
Target:
Raf,PROTACs
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