AR antagonist 9 is a potent, orally bioavailable androgen receptor (AR) antagonist that disrupts AR dimerization. It exhibits activity comparable to Enzalutamide against wild-type AR and shows superior efficacy against common resistance mutants like ARF876L/T877A. This compound demonstrates significant oral bioavailability and inhibits tumor growth in LNCaP xenograft models, supporting its research in overcoming prostate cancer resistance.
Molekulargewicht:
351.29
Formel:
C18H13F4NO2
Target-Kategorie:
Androgen Receptor
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
