AR antagonist 9 is a potent, orally bioavailable androgen receptor (AR) antagonist that disrupts AR dimerization. It exhibits activity comparable to Enzalutamide against wild-type AR and shows superior efficacy against common resistance mutants like ARF876L/T877A. This compound demonstrates significant oral bioavailability and inhibits tumor growth in LNCaP xenograft models, supporting its research in overcoming prostate cancer resistance.
Molecular Weight:
351.29
Formula:
C18H13F4NO2
Target:
Androgen Receptor
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