PROTACKSP-IN-1 (Compound 21) is a potent KSP-targeting PROTAC degrader with a DC50 of 114.8 nM in HCT-116 cells. It demonstrates strong anti-proliferative activity (IC50 = 10 nM), induces G2/M arrest and apoptosis in vitro, and shows in vivo antitumor efficacy in mouse models, supporting its use in cancer research.
Molekulargewicht:
858.01
Formel:
C48H51N5O8S
Target-Kategorie:
Apoptosis,Kinesin,PROTACs
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
