PROTACKSP-IN-1 (Compound 21) is a potent KSP-targeting PROTAC degrader with a DC50 of 114.8 nM in HCT-116 cells. It demonstrates strong anti-proliferative activity (IC50 = 10 nM), induces G2/M arrest and apoptosis in vitro, and shows in vivo antitumor efficacy in mouse models, supporting its use in cancer research.
Molecular Weight:
858.01
Formula:
C48H51N5O8S
Target:
Apoptosis,Kinesin,PROTACs
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