IRF1-IN-1 is a small molecule inhibitor of IRF1 that blocks its recruitment to the Caspase 1 promoter, thereby suppressing the cleavage of downstream targets like GSDMD, IL-1beta, and PARP1. This mechanism has shown protective effects against skin inflammation in relevant research models, making it a useful tool for studying pyroptosis and inflammatory dermatoses in vitro and in vivo.