CSF1R-IN-26, CAS [[3077238-23-1]] Preis auf Anfrage

Produktübersicht

• Artikelname: CSF1R-IN-26, CAS [[3077238-23-1]] Preis auf Anfrage
• Artikelnummer: BYT-ORB3028900
• Hersteller Artikelnummer: orb3028900
• Alternativnummer: BYT-ORB3028900-10, BYT-ORB3028900-50
• Hersteller: Biorbyt
• Kategorie: Biochemikalien

Produktbeschreibung

CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.

Produkteigenschaften

• Molekulargewicht: 415.87
• CAS Nummer: [3077238-23-1]
• Formel: C20H22ClN5O3
• Target-Kategorie: Apoptosis,c-Fms,Akt,STAT,ERK