CSF1R-IN-26, CAS [[3077238-23-1]] Preis auf Anfrage
Biozol Catalog Number:
BYT-ORB3028900
Supplier Catalog Number:
orb3028900
Alternative Catalog Number:
BYT-ORB3028900-10, BYT-ORB3028900-50
Manufacturer:
Biorbyt
Category:
Biochemikalien
CSF1R-IN-26 (Compound III-1) is an inhibitor of CSF-1R with an IC50 of 20.07 nM. It promotes the polarization of M2 macrophages to M1 macrophages, inducing apoptosis in MC-38 cancer cells. CSF1R-IN-26 inhibits the activation of the AKT/ERK/STAT3 signaling pathways, remodels the tumor immune microenvironment, and exhibits antitumor activity in mouse models. In SD rats, CSF1R-IN-26 demonstrates favorable pharmacokinetic properties, with a half-life of 1.86 hours and an oral bioavailability of 79.22%.
Molecular Weight:
415.87
CAS Number:
[3077238-23-1]
Formula:
C20H22ClN5O3
Target:
Apoptosis,c-Fms,Akt,STAT,ERK
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