[4-(Decanoylamino)benzyl]phosphonic acid (GWJ-23, GWJ-A-23)

Produktübersicht

• Artikelname: [4-(Decanoylamino)benzyl]phosphonic acid (GWJ-23, GWJ-A-23)
• Artikelnummer: ECH-L-3223
• Hersteller Artikelnummer: L-3223
• Alternativnummer: ECH-L-3223-10MG,ECH-L-3223-1MG,ECH-L-3223-5MG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

L-3223 (GWJ-23 or GWJ-A-23) is a potent inhibitor of the enzyme autotaxin (Ki = 18 nM). It is an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound. GWJ-A-23 has been shown to reduce lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-beta levels in an idiopathic pulmonary fibrosis mouse model (Ref. 2).

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Storage

-20C or below.

Featured in Publications

1) Tager, A.M. (2012) Autotaxin Emerges as a Therapeutic Target for Idiopathic Pulmonary Fibrosis: Limiting Fibrosis by Limiting Lysophosphatidic Acid Synthesis Am. J. Resp. Cell Mol. Biol. 47(5): 563-565. 2) Oikonomou, N, M.A. Mouratis, et al. (2012) Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis. Am. J. Resp. Cell Mol. Biol. 47(5): 566-574. 3) Jiang, G., D. Madan, et al. (2011). Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin. Bioorganic & Medicinal Chemistry Letters 21(17): 5098.

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Documents

Technical Data Sheet

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Biochemical Reagents. Related: Autotaxin, Inhibitor. Ship 1 : Shipping Temp. Ship 2: Gel Ice