[4-(Decanoylamino)benzyl]phosphonic acid (GWJ-23, GWJ-A-23)
Catalog Number:
ECH-L-3223
Product Overview
Article Name:
[4-(Decanoylamino)benzyl]phosphonic acid (GWJ-23, GWJ-A-23)
Biozol Catalog Number:
ECH-L-3223
Supplier Catalog Number:
L-3223
Alternative Catalog Number:
ECH-L-3223-10MG,ECH-L-3223-1MG,ECH-L-3223-5MG
Manufacturer:
Echelon Biosciences
Category:
Molekularbiologie
Product Description
L-3223 (GWJ-23 or GWJ-A-23) is a potent inhibitor of the enzyme autotaxin (Ki = 18 nM). It is an analog of the known ATX inhibitor S32826 and has improved aqueous solubility compared with the parent compound. GWJ-A-23 has been shown to reduce lung collagen, bronchoalveolar lavage cell counts, total protein, LPA, and TGF-beta levels in an idiopathic pulmonary fibrosis mouse model (Ref. 2). Storage -20C or below. Featured in Publications 1) Tager, A.M. (2012) Autotaxin Emerges as a Therapeutic Target for Idiopathic Pulmonary Fibrosis: Limiting Fibrosis by Limiting Lysophosphatidic Acid Synthesis Am. J. Resp. Cell Mol. Biol. 47(5): 563-565. 2) Oikonomou, N, M.A. Mouratis, et al. (2012) Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis. Am. J. Resp. Cell Mol. Biol. 47(5): 566-574. 3) Jiang, G., D. Madan, et al. (2011). Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin. Bioorganic & Medicinal Chemistry Letters 21(17): 5098. Documents Technical Data Sheet
Application Notes
Application Notes:
Categories: Biochemical Reagents. Related: Autotaxin, Inhibitor. Ship 1 : Shipping Temp. Ship 2: Gel Ice
