PEG2000-C-DMG

Produktübersicht

• Artikelname: PEG2000-C-DMG
• Artikelnummer: ECH-N-2012
• Hersteller Artikelnummer: N-2012
• Alternativnummer: ECH-N-2012-10MG, ECH-N-2012-1MG, ECH-N-2012-25MG, ECH-N-2012-5MG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

Patisiran is a RNAi therapeutic (brand name Onpattro) for the treatment of fatal rare disease polyneuropathy with hereditary transthyretin-mediated ( (hATTR) amyloidosis. Patisiran inhibits hepatic transthyretin protein synthesis. Lipid nanoparticle (LNP) formulation of Patisiran is composed of siRNA ALN-18328, LNP (DLin-MC3-DMA and PEG2000-C-DMG) and lipid (DSPC and cholesterol). PEG2000-C-DMG provides a hydrophilic steric barrier that inhibits the binding of plasma proteins, including opsonins, and increases the site-specific delivery of siRNA ALN-18328.

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Helper Lipids, Lipids