PEG2000-C-DMG

Product Overview

• Article Name: PEG2000-C-DMG
• Biozol Catalog Number: ECH-N-2012
• Supplier Catalog Number: N-2012
• Alternative Catalog Number: ECH-N-2012-10MG, ECH-N-2012-1MG, ECH-N-2012-25MG, ECH-N-2012-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

Patisiran is a RNAi therapeutic (brand name Onpattro) for the treatment of fatal rare disease polyneuropathy with hereditary transthyretin-mediated ( (hATTR) amyloidosis. Patisiran inhibits hepatic transthyretin protein synthesis. Lipid nanoparticle (LNP) formulation of Patisiran is composed of siRNA ALN-18328, LNP (DLin-MC3-DMA and PEG2000-C-DMG) and lipid (DSPC and cholesterol). PEG2000-C-DMG provides a hydrophilic steric barrier that inhibits the binding of plasma proteins, including opsonins, and increases the site-specific delivery of siRNA ALN-18328.

Application Notes

• Application Notes: Categories: Helper Lipids, Lipids