S1P Lyase Fluorogenic Substrate

Produktübersicht

• Artikelname: S1P Lyase Fluorogenic Substrate
• Artikelnummer: ECH-S-200U
• Hersteller Artikelnummer: S-200U
• Alternativnummer: ECH-S-200U-10MG,ECH-S-200U-1MG,ECH-S-200U-5MG
• Hersteller: Echelon Biosciences
• Kategorie: Molekularbiologie

Produktbeschreibung

S1P Lyase Fluorogenic Substrate is designed for monitoring S1PL activity by releasing fluorescent 7-hydroxycoumarin in the presence of active enzyme. Sphingosine-1-phosphate lyase (S1PL) is an enzyme that breaks sphingosine-1-phosphate into hexadecenal and phosphoethanolamine. S1PL has been proposed as a target for autoimmune disorder treatment and in cancer therapy.

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Storage

-20C or below.

References

1. Billich, A., et al. (2013). Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis. PLoS One 8(3): e59630. 2. Engel, N., et al. (2012). Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A. PLoS One 7(10): e47833. 3. Bedia, C., et al. (2009). Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity. Chembiochem 10(5): 820-2.

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Documents

Technical Data Sheet

Anwendungsbeschreibung

• Anwendungsbeschreibung: Categories: Lipids. Related: Sphingolipid, Sphingosine 1-phosphate. Ship 1 : Shipping Temp. Ship 2: Dry ice or gel ice depending on destination