S1P Lyase Fluorogenic Substrate

Product Overview

• Article Name: S1P Lyase Fluorogenic Substrate
• Biozol Catalog Number: ECH-S-200U
• Supplier Catalog Number: S-200U
• Alternative Catalog Number: ECH-S-200U-10MG,ECH-S-200U-1MG,ECH-S-200U-5MG
• Manufacturer: Echelon Biosciences
• Category: Molekularbiologie

Product Description

S1P Lyase Fluorogenic Substrate is designed for monitoring S1PL activity by releasing fluorescent 7-hydroxycoumarin in the presence of active enzyme. Sphingosine-1-phosphate lyase (S1PL) is an enzyme that breaks sphingosine-1-phosphate into hexadecenal and phosphoethanolamine. S1PL has been proposed as a target for autoimmune disorder treatment and in cancer therapy.

---

Storage

-20C or below.

References

1. Billich, A., et al. (2013). Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis. PLoS One 8(3): e59630. 2. Engel, N., et al. (2012). Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A. PLoS One 7(10): e47833. 3. Bedia, C., et al. (2009). Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity. Chembiochem 10(5): 820-2.

---

Documents

Technical Data Sheet

Application Notes

• Application Notes: Categories: Lipids. Related: Sphingolipid, Sphingosine 1-phosphate. Ship 1 : Shipping Temp. Ship 2: Dry ice or gel ice depending on destination