FUS / TLS (18I13) Rabbit Monoclonal Antibody, Unconjugated

Produktübersicht

• Artikelname: FUS / TLS (18I13) Rabbit Monoclonal Antibody, Unconjugated
• Artikelnummer: EKL-AMRE11186
• Hersteller Artikelnummer: AMRe11186
• Alternativnummer: EKL-AMRE11186-50UL, EKL-AMRE11186-100UL, EKL-AMRE11186-200UL
• Hersteller: EnkiLife
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: FC, ICC, IHC, WB
• Spezies Reaktivität: Human
• Konjugation: Unconjugated
• Alternative Synonym: FUS, ALS6, CHOP, FUS-CHOP, FUS1, Fused in sarcoma, HnRNPP2, Oncogene TLS, ETM4, Fus-like protein, Oncogene FUS, POMP75,

Produktbeschreibung

FUS/TLS (fused in sarcoma/translocated in liposarcoma) was initially identified by investigators as a component of fusion proteins found in a variety of cancers such as myxoid liposarcoma, acute myeloid leukemia, and Ewings tumor. DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre- mRNA and autoregulates its expression, this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity).

Produkteigenschaften

• Klonalität: Monoclonal
• Molekulargewicht: 53kDa
• NCBI: 2521
• UniProt: P35637
• Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Reinheit: Affinity purification
• Formulierung: Liquid
• Target-Kategorie: FUS

Anwendungsbeschreibung

• Application Verdünnung: WB 1:500-1:2000,IHC 1:200-1:1000,ICC/IF 1:100-1:200,FC 1:50-1:200