FUS / TLS (18I13) Rabbit Monoclonal Antibody, Unconjugated

Product Overview

• Article Name: FUS / TLS (18I13) Rabbit Monoclonal Antibody, Unconjugated
• Biozol Catalog Number: EKL-AMRE11186
• Supplier Catalog Number: AMRe11186
• Alternative Catalog Number: EKL-AMRE11186-50UL, EKL-AMRE11186-100UL, EKL-AMRE11186-200UL
• Manufacturer: EnkiLife
• Host: Rabbit
• Category: Antikörper
• Application: FC, ICC, IHC, WB
• Species Reactivity: Human
• Conjugation: Unconjugated
• Alternative Names: FUS, ALS6, CHOP, FUS-CHOP, FUS1, Fused in sarcoma, HnRNPP2, Oncogene TLS, ETM4, Fus-like protein, Oncogene FUS, POMP75,

Product Description

FUS/TLS (fused in sarcoma/translocated in liposarcoma) was initially identified by investigators as a component of fusion proteins found in a variety of cancers such as myxoid liposarcoma, acute myeloid leukemia, and Ewings tumor. DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre- mRNA and autoregulates its expression, this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity).

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 53kDa
• NCBI: 2521
• UniProt: P35637
• Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Purity: Affinity purification
• Form: Liquid
• Target: FUS

Application Notes

• Application Dilute: WB 1:500-1:2000,IHC 1:200-1:1000,ICC/IF 1:100-1:200,FC 1:50-1:200