GABA B Receptor 1 (17L17) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE11228
Produktübersicht
Artikelname:
GABA B Receptor 1 (17L17) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE11228
Hersteller Artikelnummer:
AMRe11228
Alternativnummer:
EKL-AMRE11228-50UL, EKL-AMRE11228-100UL, EKL-AMRE11228-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IF, IHC, WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
GABA-B receptor 1, GABA-B-R1, GABAB R1, GABAB subunit 1c, GABABR1, GABBR1 3, Gamma aminobutyric acid (GABA) B receptor 1, Gb1, GPRC3A,
Produktbeschreibung
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed: 9872744, PubMed: 15617512, PubMed: 18165688, PubMed: 22660477, PubMed: 24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed: 18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed: 10906333, PubMed: 10773016, PubMed: 10075644, PubMed: 9872744, PubMed: 24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed: 10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine- tuning of inhibitory synaptic transmission (PubMed: 9844003). Pre- synaptic GABA receptor inhibits neurotransmitter release by down- regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed: 9844003, PubMed: 9872316, PubMed: 10075644, PubMed: 9872744, PubMed: 22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed: 9844003, PubMed: 9872316, PubMed: 24305054).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
108kDa
NCBI:
2550
UniProt:
Q9UBS5
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
GABBR1
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000,IHC 1:200-1:500,IF-P 1:200-1:500
