GABA B Receptor 1 (17L17) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE11228
Product Overview
Article Name:
GABA B Receptor 1 (17L17) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE11228
Supplier Catalog Number:
AMRe11228
Alternative Catalog Number:
EKL-AMRE11228-50UL, EKL-AMRE11228-100UL, EKL-AMRE11228-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
IF, IHC, WB
Species Reactivity:
Human, Mouse, Rat
Conjugation:
Unconjugated
Alternative Names:
GABA-B receptor 1, GABA-B-R1, GABAB R1, GABAB subunit 1c, GABABR1, GABBR1 3, Gamma aminobutyric acid (GABA) B receptor 1, Gb1, GPRC3A,
Product Description
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed: 9872744, PubMed: 15617512, PubMed: 18165688, PubMed: 22660477, PubMed: 24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed: 18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed: 10906333, PubMed: 10773016, PubMed: 10075644, PubMed: 9872744, PubMed: 24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed: 10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine- tuning of inhibitory synaptic transmission (PubMed: 9844003). Pre- synaptic GABA receptor inhibits neurotransmitter release by down- regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed: 9844003, PubMed: 9872316, PubMed: 10075644, PubMed: 9872744, PubMed: 22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed: 9844003, PubMed: 9872316, PubMed: 24305054).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
108kDa
NCBI:
2550
UniProt:
Q9UBS5
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
GABBR1
Application Notes
Application Dilute:
WB 1:500-1:2000,IHC 1:200-1:500,IF-P 1:200-1:500
