Granulin (18Q13) Rabbit Monoclonal Antibody, Unconjugated

Produktübersicht

• Artikelname: Granulin (18Q13) Rabbit Monoclonal Antibody, Unconjugated
• Artikelnummer: EKL-AMRE11737
• Hersteller Artikelnummer: AMRe11737
• Alternativnummer: EKL-AMRE11737-50UL, EKL-AMRE11737-100UL, EKL-AMRE11737-200UL
• Hersteller: EnkiLife
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IF, IHC, IP, WB
• Spezies Reaktivität: Human
• Konjugation: Unconjugated
• Alternative Synonym: Acrogranin, CLN11, GEP, GP88, Granulins, GRN, PCDGF, PEPI, PGRN, Proepithelin, Progranulin,

Produktbeschreibung

Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:28541286, PubMed:28073925, PubMed:18378771, PubMed:28453791, PubMed:12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771).

Produkteigenschaften

• Klonalität: Monoclonal
• Molekulargewicht: 64kDa
• NCBI: 2896
• UniProt: P28799
• Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Reinheit: Affinity purification
• Formulierung: Liquid
• Target-Kategorie: GRN

Anwendungsbeschreibung

• Application Verdünnung: WB 1:500-1:2000,IHC 1:200-1:1000,IP 1:50-1:100,IF-P 1:200-1:1000