Granulin (18Q13) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE11737
Product Overview
Article Name:
Granulin (18Q13) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE11737
Supplier Catalog Number:
AMRe11737
Alternative Catalog Number:
EKL-AMRE11737-50UL, EKL-AMRE11737-100UL, EKL-AMRE11737-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
IF, IHC, IP, WB
Species Reactivity:
Human
Conjugation:
Unconjugated
Alternative Names:
Acrogranin, CLN11, GEP, GP88, Granulins, GRN, PCDGF, PEPI, PGRN, Proepithelin, Progranulin,
Product Description
Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:28541286, PubMed: 28073925, PubMed: 18378771, PubMed: 28453791, PubMed: 12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed: 28453791, PubMed: 28541286). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed: 28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed: 12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed: 18378771).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
64kDa
NCBI:
2896
UniProt:
P28799
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
GRN
Application Notes
Application Dilute:
WB 1:500-1:2000,IHC 1:200-1:1000,IP 1:50-1:100,IF-P 1:200-1:1000
