Hepcidin (16X4) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE11984
Produktübersicht
Artikelname:
Hepcidin (16X4) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE11984
Hersteller Artikelnummer:
AMRe11984
Alternativnummer:
EKL-AMRE11984-50UL, EKL-AMRE11984-100UL, EKL-AMRE11984-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Rat
Konjugation:
Unconjugated
Alternative Synonym:
Hepcidin, Liver-expressed antimicrobial peptide 1, LEAP-1, Putative liver tumor regressor, PLTR, Hepcidin-25, Hepc25, Hepcidin-20, Hepc20, HAMP, HEPC, LEAP1,
Produktbeschreibung
Hepcidin, also known as HAMP, HEPC, LEAP1 or HFE2B, is an 84 amino acid secreted protein that regulates iron-related signaling events. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PubMed:22682227, PubMed: 29237594, PubMed: 32814342). Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed: 22306005).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
9kDa
NCBI:
57817
UniProt:
P81172
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
HAMP
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000
