Hepcidin (16X4) Rabbit Monoclonal Antibody, Unconjugated

Product Overview

• Article Name: Hepcidin (16X4) Rabbit Monoclonal Antibody, Unconjugated
• Biozol Catalog Number: EKL-AMRE11984
• Supplier Catalog Number: AMRe11984
• Alternative Catalog Number: EKL-AMRE11984-50UL, EKL-AMRE11984-100UL, EKL-AMRE11984-200UL
• Manufacturer: EnkiLife
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Human, Rat
• Conjugation: Unconjugated
• Alternative Names: Hepcidin, Liver-expressed antimicrobial peptide 1, LEAP-1, Putative liver tumor regressor, PLTR, Hepcidin-25, Hepc25, Hepcidin-20, Hepc20, HAMP, HEPC, LEAP1,

Product Description

Hepcidin, also known as HAMP, HEPC, LEAP1 or HFE2B, is an 84 amino acid secreted protein that regulates iron-related signaling events. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342). Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 9kDa
• NCBI: 57817
• UniProt: P81172
• Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Purity: Affinity purification
• Form: Liquid
• Target: HAMP

Application Notes

• Application Dilute: WB 1:500-1:2000