PI 3 kinase p110 alpha (8X14) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE16092
Produktübersicht
Artikelname:
PI 3 kinase p110 alpha (8X14) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE16092
Hersteller Artikelnummer:
AMRe16092
Alternativnummer:
EKL-AMRE16092-50UL, EKL-AMRE16092-100UL, EKL-AMRE16092-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ICC, IP, WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
PI 3 Kinase catalytic subunit alpha, phosphoinositide-3-kinase catalytic alpha polypeptide, PI3-kinase p110 alpha, PI3K, PI3K p110-alpha, PK3CA, PIK3CA, PtdIns-3-kinase p110
Produktbeschreibung
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396, PubMed: 23936502, PubMed: 28676499). Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) (PubMed: 15135396, PubMed: 28676499). PIP3 plays a key role by recruiting PH domain- containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others (PubMed: 23936502, PubMed: 28676499). Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
124kDa
NCBI:
5290
UniProt:
P42336
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
PIK3CA
Anwendungsbeschreibung
Application Verdünnung:
WB 1:1000-1:5000,ICC/IF 1:100-1:200,IP 1:20-1:50
