PI3 Kinase p85 alpha (4H15) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE16111
Produktübersicht
Artikelname:
PI3 Kinase p85 alpha (4H15) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE16111
Hersteller Artikelnummer:
AMRe16111
Alternativnummer:
EKL-AMRE16111-50UL, EKL-AMRE16111-100UL, EKL-AMRE16111-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
GRB1, p85 alpha, PI3-kinase subunit p85-alpha, PI3K, PI3K regulatory subunit alpha, Pik3r1, PtdIns 3 kinase p85 alpha,
Produktbeschreibung
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed: 19805105, PubMed: 7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed: 20348923).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
84kDa
NCBI:
5295
UniProt:
P27986
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
PIK3R1
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000
