PI3 Kinase p85 alpha (4H15) Rabbit Monoclonal Antibody, Unconjugated

Product Overview

• Article Name: PI3 Kinase p85 alpha (4H15) Rabbit Monoclonal Antibody, Unconjugated
• Biozol Catalog Number: EKL-AMRE16111
• Supplier Catalog Number: AMRe16111
• Alternative Catalog Number: EKL-AMRE16111-50UL, EKL-AMRE16111-100UL, EKL-AMRE16111-200UL
• Manufacturer: EnkiLife
• Host: Rabbit
• Category: Antikörper
• Application: WB
• Species Reactivity: Human, Mouse, Rat
• Conjugation: Unconjugated
• Alternative Names: GRB1, p85 alpha, PI3-kinase subunit p85-alpha, PI3K, PI3K regulatory subunit alpha, Pik3r1, PtdIns 3 kinase p85 alpha,

Product Description

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 84kDa
• NCBI: 5295
• UniProt: P27986
• Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Purity: Affinity purification
• Form: Liquid
• Target: PIK3R1

Application Notes

• Application Dilute: WB 1:500-1:2000