RPE65 (5T1) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE17356
Produktübersicht
Artikelname:
RPE65 (5T1) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE17356
Hersteller Artikelnummer:
AMRe17356
Alternativnummer:
EKL-AMRE17356-50UL, EKL-AMRE17356-100UL, EKL-AMRE17356-200UL
Hersteller:
EnkiLife
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IF, IHC, IP, WB
Spezies Reaktivität:
Human, Mouse, Rat
Konjugation:
Unconjugated
Alternative Synonym:
LCA2, mRPE65, p63, rd12, Retinal pigment epithelium specific 61 kDa protein, RP20, RPE65, sRPE65,
Produktbeschreibung
Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16116091). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed: 17848510). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye- specific carotenoid (PubMed: 28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all- trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity).
Produkteigenschaften
Klonalität:
Monoclonal
Molekulargewicht:
61kDa
NCBI:
6121
UniProt:
Q16518
Puffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Reinheit:
Affinity purification
Formulierung:
Liquid
Target-Kategorie:
RPE65
Anwendungsbeschreibung
Application Verdünnung:
WB 1:500-1:2000,IHC 1:500-1:2000,IP 1:20-1:50,IF-P 1:500-1:2000
