TMPRSS2 (6M19) Rabbit Monoclonal Antibody, Unconjugated

Produktübersicht

• Artikelname: TMPRSS2 (6M19) Rabbit Monoclonal Antibody, Unconjugated
• Artikelnummer: EKL-AMRE19071
• Hersteller Artikelnummer: AMRe19071
• Alternativnummer: EKL-AMRE19071-50UL,EKL-AMRE19071-100UL,EKL-AMRE19071-500UL,EKL-AMRE19071-200UL
• Hersteller: EnkiLife
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: IHC, WB
• Spezies Reaktivität: Human, Mouse, Rat
• Konjugation: Unconjugated
• Alternative Synonym: Epitheliasin, PRSS10, TMPRSS2,

Produktbeschreibung

Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions, spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).

Produkteigenschaften

• Klonalität: Monoclonal
• Molekulargewicht: 54kDa
• NCBI: 7113
• UniProt: O15393
• Puffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Reinheit: Affinity purification
• Formulierung: Liquid
• Target-Kategorie: TMPRSS2

Anwendungsbeschreibung

• Application Verdünnung: WB 1:500-1:2000,IHC 1:200-1:1000