TMPRSS2 (6M19) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE19071
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| Article Name: | TMPRSS2 (6M19) Rabbit Monoclonal Antibody, Unconjugated |
| Biozol Catalog Number: | EKL-AMRE19071 |
| Supplier Catalog Number: | AMRe19071 |
| Alternative Catalog Number: | EKL-AMRE19071-50UL,EKL-AMRE19071-100UL,EKL-AMRE19071-500UL,EKL-AMRE19071-200UL |
| Manufacturer: | EnkiLife |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | IHC, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Conjugation: | Unconjugated |
| Alternative Names: | Epitheliasin, PRSS10, TMPRSS2, |
| Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions, spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). |
| Clonality: | Monoclonal |
| Molecular Weight: | 54kDa |
| NCBI: | 7113 |
| UniProt: | O15393 |
| Buffer: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle. |
| Purity: | Affinity purification |
| Form: | Liquid |
| Target: | TMPRSS2 |
| Application Dilute: | WB 1:500-1:2000,IHC 1:200-1:1000 |
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