TMPRSS2 (6M19) Rabbit Monoclonal Antibody, Unconjugated

Product Overview

• Article Name: TMPRSS2 (6M19) Rabbit Monoclonal Antibody, Unconjugated
• Biozol Catalog Number: EKL-AMRE19071
• Supplier Catalog Number: AMRe19071
• Alternative Catalog Number: EKL-AMRE19071-50UL, EKL-AMRE19071-100UL, EKL-AMRE19071-200UL
• Manufacturer: EnkiLife
• Host: Rabbit
• Category: Antikörper
• Application: IHC, WB
• Species Reactivity: Human, Mouse, Rat
• Conjugation: Unconjugated
• Alternative Names: Epitheliasin, PRSS10, TMPRSS2,

Product Description

Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions, spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).

Product Properties

• Clonality: Monoclonal
• Molecular Weight: 54kDa
• NCBI: 7113
• UniProt: O15393
• Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
• Purity: Affinity purification
• Form: Liquid
• Target: TMPRSS2

Application Notes

• Application Dilute: WB 1:500-1:2000,IHC 1:200-1:1000