Inhibitor of G2 DNA damage checkpoint (IC50=8µM) and check point kinases 1 (Chk1) (IC50=3µM) and 2 (Chk2) (IC50=3.5µM). Unlike other checkpoint inhibitors DBH does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related protein. Also inhibits
Molekulargewicht:
245.2
Quelle:
Isolated from sponge Axinella carteri.
Reinheit:
95% (HPLC)
CAS Nummer:
[75593-17-8]
Formel:
C11H11N5O2
Target-Kategorie:
Chk1, ChK2
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