Inhibitor of G2 DNA damage checkpoint (IC50=8µM) and check point kinases 1 (Chk1) (IC50=3µM) and 2 (Chk2) (IC50=3.5µM). Unlike other checkpoint inhibitors DBH does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related protein. Also inhibits
Molecular Weight:
245.2
Source:
Isolated from sponge Axinella carteri.
Purity:
95% (HPLC)
CAS Number:
[75593-17-8]
Formula:
C11H11N5O2
Target:
Chk1, ChK2
* VAT and and shipping costs not included. Errors and price changes excepted