Anti-Granzyme B FITC, Clone: [CLB-GB11], Monoclonal

Produktübersicht

• Artikelname: Anti-Granzyme B FITC, Clone: [CLB-GB11], Monoclonal
• Artikelnummer: EXB-1F-634-T100
• Hersteller Artikelnummer: 1F-634-T100
• Alternativnummer: EXB-1F-634-T100
• Hersteller: EXBIO
• Kategorie: Antikörper
• Applikation: FC
• Spezies Reaktivität: Human, Primate
• Immunogen: Human NK cell line YT-INDY-derived granzyme B
• Konjugation: FITC

Produktbeschreibung

Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [CLB-GB11]
• Isotyp: Mouse IgG1
• Puffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Target-Kategorie: Granzyme B
• Antibody Type: Monoclonal Antibody

Anwendungsbeschreibung

• Anwendungsbeschreibung: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. Intracellular staining.