Anti-Granzyme B FITC, Clone: [CLB-GB11], Monoclonal

Product Overview

• Article Name: Anti-Granzyme B FITC, Clone: [CLB-GB11], Monoclonal
• Biozol Catalog Number: EXB-1F-634-T100
• Supplier Catalog Number: 1F-634-T100
• Alternative Catalog Number: EXB-1F-634-T100
• Manufacturer: EXBIO
• Category: Antikörper
• Application: FC
• Species Reactivity: Human, Primate
• Immunogen: Human NK cell line YT-INDY-derived granzyme B
• Conjugation: FITC

Product Description

Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.

Product Properties

• Clonality: Monoclonal
• Clone Designation: [CLB-GB11]
• Isotype: Mouse IgG1
• Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Target: Granzyme B
• Antibody Type: Monoclonal Antibody

Application Notes

• Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 µl reagent / 100 µl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. Intracellular staining.