LFM-A13, CAS [[244240-24-2]]

Produktübersicht

• Artikelname: LFM-A13, CAS [[244240-24-2]]
• Artikelnummer: FBM-10-1032
• Hersteller Artikelnummer: 10-1032
• Alternativnummer: FBM-10-1032-5MG, FBM-10-1032-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide

Produktbeschreibung

BTK inhibitor

Produkteigenschaften

• Molekulargewicht: 360.00
• Reinheit: 98% by TLC, NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [244240-24-2]
• Formel: C11H8Br2N2O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: LFM-A13 is a selective inhibitor of Brutons tyrosine kinase (BTK) - IC50s = 2.5 µM (recombinant BTK) and 17.2 µM (human BTK).1,2 It has also been shown to inhibit Polo-ilke kinase (PLK) - IC50 = 61 µM for human PLK3.3 It displayed no activity (concentrations up to 278 µM) at JAK1, JAK3, HCK, EGFRK and IRK2 or CDK1-3, CHK1, IKK, MAPK1, SAPK2a and ten tyrosine kinases3.