LFM-A13, CAS [[244240-24-2]]

Product Overview

• Article Name: LFM-A13, CAS [[244240-24-2]]
• Biozol Catalog Number: FBM-10-1032
• Supplier Catalog Number: 10-1032
• Alternative Catalog Number: FBM-10-1032-5MG, FBM-10-1032-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide

Product Description

BTK inhibitor

Product Properties

• Molecular Weight: 360.00
• Purity: 98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [244240-24-2]
• Formula: C11H8Br2N2O2

Application Notes

• Application Notes: LFM-A13 is a selective inhibitor of Brutons tyrosine kinase (BTK) - IC50s = 2.5 µM (recombinant BTK) and 17.2 µM (human BTK).1,2 It has also been shown to inhibit Polo-ilke kinase (PLK) - IC50 = 61 µM for human PLK3.3 It displayed no activity (concentrations up to 278 µM) at JAK1, JAK3, HCK, EGFRK and IRK2 or CDK1-3, CHK1, IKK, MAPK1, SAPK2a and ten tyrosine kinases3.