Chemical Name: Anthra[1-9-cd]pyrazol-6(2H)-one. Alternate Names: 1,9-Pyrazoloanthrone
JNK inhibitor
Molekulargewicht:
220.23
Reinheit:
98% by TLC NMR conforms
Formulierung:
Yellow solid
CAS Nummer:
[129-56-6]
Formel:
C14H8N2O
Anwendungsbeschreibung:
Selective inhibitor of c-Jun N-terminal kinase (JNK). Reversibly inhibits JNK1,2 and 3 (IC50s range from 40-90 nM). >300-fold selectivity for JNK as compared to related MAP kinases. Antiinflammatory activity. Inhibits expression of presenilin-1 and Notch signaling in mouse brain. Cell permeable and active in vivo.
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