Chemical Name: 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
CAMKK inhibitor
Molekulargewicht:
314.30 60.05
Reinheit:
98% by TLC NMR conforms
Formulierung:
Yellow solid
CAS Nummer:
[52029-86-4]
Formel:
C19H10N2O3 CH3COOH
Anwendungsbeschreibung:
Selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKalpha and CaM-KKbeta respectively).1 Binds to the ATP-binding site.2 Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Important tool for probing distinct CaMK pathways in LTP.3 Reduces starvation-induced autophagosomal membrane formation.4 Reverses age-associated decline in bone mass.5 Stimulates osteoblast formation, inhibits osteoclast differentiation.6
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