Chemical Name: N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimehyl-1H-pyrrole-3-carboxamide malate. Alternate Names: SU-11248
VEGFR, PDGFR kinase inhibitor
Molekulargewicht:
532.57
Reinheit:
98% by TLC, NMR (Conforms)
Formulierung:
Orange solid
CAS Nummer:
[341031-54-7]
Formel:
C22H27FN4O4 C4H6O5
Anwendungsbeschreibung:
A potent inhibitor of multiple receptor tyrosine kinases including VEGFR, PDGFRbeta and Kit (Ki = 2-17 nM)1. Also inhibits cFMS (IC50=7 nM)2 and FLT33. Potent inhibitor of angiogenesis4. Clinically useful anticancer agent. Cell permeable.
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