Chemical Name: N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium. Alternate Names: ONO-5046
Leukocyte elastase inhibitor
Molekulargewicht:
456.45
Reinheit:
98% by TLC
Formulierung:
White solid
CAS Nummer:
[127373-66-4]
Formel:
C20H21N2O7
Anwendungsbeschreibung:
Potent and selective leukocyte elastase inhibitor, IC50 = 44 nM1. Displays no activity at a variety of other proteases. Inhibits NF-kappaB activation2 and LTB4-induced neutrophil migration in vitro3. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo4.
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