Chemical Name: (3alpha,16alpha)-Eburnamenine-14-carboxylic acid ethyl ester
PDE1 inhibitor
Molekulargewicht:
350.45
Reinheit:
98% by TLC, NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[42971-09-5]
Formel:
C22H26N2O2
Anwendungsbeschreibung:
Phosphodiesterase PDE1 inhibitor (IC50=21 µM)1. Also blocks voltage-gated Na+ channels, IC50=44.2 µM (potency similar to phenytoin), a mechanism which may contribute to its neuroprotective and anticonvulsant activity2. It reduces inflammatory IL-1beta and TNF-alpha expression in rat hippocampus3. Displays beneficial effects in a rat model of cerebral ischemia-reperfusion injury4. Exerts neuroprotective effects by suppressing microglial inflammation5.
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten