Chemical Name: (3alpha,16alpha)-Eburnamenine-14-carboxylic acid ethyl ester
PDE1 inhibitor
Molecular Weight:
350.45
Purity:
98% by TLC, NMR (Conforms)
Form:
White solid
CAS Number:
[42971-09-5]
Formula:
C22H26N2O2
Application Notes:
Phosphodiesterase PDE1 inhibitor (IC50=21 µM)1. Also blocks voltage-gated Na+ channels, IC50=44.2 µM (potency similar to phenytoin), a mechanism which may contribute to its neuroprotective and anticonvulsant activity2. It reduces inflammatory IL-1beta and TNF-alpha expression in rat hippocampus3. Displays beneficial effects in a rat model of cerebral ischemia-reperfusion injury4. Exerts neuroprotective effects by suppressing microglial inflammation5.
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