Chemical Name: 2-(N-Benzylanilinomethyl)-2-imidazoline hydrochloride
Antihistamine and neuroprotective
Molekulargewicht:
301.82
Reinheit:
>98% by TLC, NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[2508-72-7]
Formel:
C17H19N3 HCl
Anwendungsbeschreibung:
Antazoline (2508-72-7) displays neuroprotective effects against hypoxia-induced death in neuronal cultures, the mechanism of action being inhibition of NMDA currents (IC50=4 µM).1 It induces concentration-dependent stimulation of insulin secretion in rat pancreas which is mediated via imidazoline I1 receptors.2 It also acts as a histamine H1 receptor antagonist (Ki=38.4 nM, human recombinant H1 receptor)3 and was found to be a highly effective antiarrhythmic agent4.
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