Chemical Name: 2,3-Didehydro-3-deoxythymidine. Alternate Names: BMY 27857, d4T
HIV reverse transcriptase inhibitor
Molekulargewicht:
224.22
Reinheit:
>98% by HPLC, NMR (conforms)
Formulierung:
White solid
CAS Nummer:
[3056-17-5]
Formel:
C10H12N2O4
Anwendungsbeschreibung:
Thymidine derivative that acts as an HIV nucleoside reverse transcriptase inhibitor (NRTI) (EC50 = 8.8 nM for HIV-1 replication in human PBMCs).1,2 Down-modulates P2X7-mediated NLRP3 inflammasome activation independent of reverse transcriptase inhibition.3 Reduces production of IL-18 and caspase-1 and stimulates Abeta-induced autophagy in macrophages.4
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