Chemical Name: 2-Deoxy-5-trifluoromethyluridine. Alternate Names: alpha,alpha,alpha-Trifluorothymidine, Trifluorothymine deoxyriboside, Trifluridine, TFT
Thymidylate synthase inhibitor, Anti-cancer agent
Molekulargewicht:
296.20
Reinheit:
98% by HPLC, NMR (Conforms)
Formulierung:
Off-white solid
CAS Nummer:
[70-00-8]
Formel:
C10H11F3N2O5
Anwendungsbeschreibung:
An analog of thymidine which inhibits thymidylate synthase possesses antiviral and anticancer activity.1,2 After phosphorylation by thymidine kinase, it is incorporated into DNA where it induces DNA-damage and interferes with repair enzymes.3 Enhances frame shift insertion and deletion in CRISPR genome editing in pluripotent stem cells.4
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