SR-1001, CAS [[1335106-03-0]]

Produktübersicht

• Artikelname: SR-1001, CAS [[1335106-03-0]]
• Artikelnummer: FBM-10-1290
• Hersteller Artikelnummer: 10-1290
• Alternativnummer: FBM-10-1290-5MG, FBM-10-1290-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide

Produktbeschreibung

RORag inverse agonist

Produkteigenschaften

• Molekulargewicht: 477.39
• Reinheit: 98% by TLC, NMR (conforms)
• Formulierung: Cream-colored solid
• CAS Nummer: [1335106-03-0]
• Formel: C15H13F6N6O4S2

Anwendungsbeschreibung

• Anwendungsbeschreibung: A high affinity synthetic ligand for both RORalpha and RORgammat acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to diminished affinity for co-activators and increased affinity for co-repressors resulting in suppression of transcriptional activity1. It inhibits the development of murine TH17 cells2 and suppresses the expression of cytokines1. Suppresses insulitis and prevents hyperglycemia in a type 1 diabetes mouse model3. Protects against pathologic neovascularization in various mouse models of retinopathy4. Active in vivo